Recently, Quyn et al. demonstrated that cells within the stem cell zone of human and mouse intestinal crypts tend to align their mitotic spindles perpendicular to the basal membrane of the crypt. This is associated with asymmetric division, whereby particular proteins and individual chromatids are preferentially segregated to one daughter cell. In colonic mucosa containing a heterozygous adenomatous polyposis coli gene (APC) mutation the asymmetry is lost. Here, we discuss asymmetric stem cell division as an anti‐tumourigenic mechanism. We describe how (...) hierarchical tissue structures suppress somatic evolution, and discuss the relative merits of template strand retention to limit the accumulation of DNA replication errors. We suggest experiments to determine whether somatic mutations resulting in loss of spindle alignment confer an advantage within the stem cell niche. Finally, we discuss whether lack of spindle alignment constitutes an oncogenic event per se, with particular reference to studies in model organisms, and the timing of chromosomal instability in human cancers. (shrink)

The Canadian province of Ontario introduced philosophy as a secondary school subject in 1995 (Pinto, McDonough, & Boyd, 2009). Since publicly-funded Catholic schools teach approximately 32% of all students in Ontario (Ontario Ministry of Education, 2022), the question arises regarding how teachers in those schools coordinate philosophy and Catholic teachings. This study employs a secondary analysis of interviews with six teachers from Ontario’s Catholic schools, and employs two of Avery Dulles’ (2002) conceptions of church (institution and mystical communion) to determine (...) how they consider the choices available within their own tradition that could answer this question. Rather than looking only at the shortcomings of treating magisterial teaching as philosophy, this paper argues that there are also conceptual problems that these courses must address in order to improve their ecclesiological adequacy, and illustrates how an apparent null curriculum privileges the institutional ecclesiology. (shrink)

"This innovative volume argues that any particular kind of music can only be understood in terms of the criteria of the group which makes and appreciates that music. This theme is in sharp contrast to established attitudes to music which utilize 'objectively' conceived aesthetic. These attitudes are revealed in the assumptions underlying most musicology and musical aesthetics including, perhaps paradoxically, the work of a number of cultural radicals such as Lukacs and Adorno. On a more practical level, they manifest themselves (...) both in music education policies and in the policies of arts and broadcasting administrators, who have the power to promote some kinds of music above others. (shrink)

The Problem of Consciousness This chapter will introduce you to consciousness and its most important characteristics. We will look at definitions of consciousness, and examine what it means to say that consciousness is a private experience. We will look at the idea that it is like something to be you or me. The chapter mentions ideas and themes that will be covered in more detail in the rest of the book, and explains why the topic is an important one. Research (...) on consciousness is big on questions but shorter on answers. Nevertheless these questions are central to what it means to be human, or indeed at the heart of what it's like to be anything - what it's like to be conscious. Think of yourself just now. What does it feel like you to be you right at this moment? Think of a loved one. What do you think it is like to be them? Do they know exactly what they're feeling, and do you know just what they're feeling? We might have some idea, but the answer in both cases is no, and not only "no", we can't see how we ever could know for sure. It's my consciousness and your consciousness. (shrink)

Constraints on the types of speech errors observed can be accounted for by a frame/content distinction, but connectionist modeling shows that they do not require this distinction. The constraints may arise instead from the statistical properties of our language, in particular, the sequential biases observed in the vocabulary. Nevertheless, there might still be a role for the frame/content distinction in syntactic planning.

This paper considers the claim that imagination is implicated in our most apparently straightforward human transactions with the world, that our 'knowing' of the world (both in experience and our subsequent symbolic ordering of it) is in some sense imaginatively constructed from the outset. Second, drawing in particular on the work of Mark Johnson, it explores the senses in which such imaginative transactions are both experience constituted and experience constitutive (that, in Ricoeur's words, imagination 'invents in both senses of the (...) word'). Third, it attends to one apparent theological cost of ascribing to human imagination a 'creative' role in relation to the human world. Fourth, it focuses in particular on Charles Taylor's account of the imaginative construction of the self as a moral entity. And finally, it considers just one example of how the arts may be active in shaping moral identity, and thereby the human world in which we live and move and have our being. (shrink)

The history of the Euclidean Steiner tree problem, which is the problem of constructing a shortest possible network interconnecting a set of given points in the Euclidean plane, goes back to Gergonne in the early nineteenth century. We present a detailed account of the mathematical contributions of some of the earliest papers on the Euclidean Steiner tree problem. Furthermore, we link these initial contributions with results from the recent literature on the problem.

Evolving the Mind has two main themes: how ideas about the mind evolved in science; and how the mind itself evolved in nature. The mind came into physical science when it was realised, first, that it is the activity of a physical object, a brain, which makes a mind; and secondly, that our theories of nature are largely mental constructions, artificial extensions of an inner model of the world which we inherited from our distant ancestors. From both of these perspectives, (...) consciousness is the great enigma. If consciousness evolved, however, it is in some sense a material thing whatever else may be said of it. Physics, chemistry, molecular biology, brain function and evolutionary biology - almost the whole of science - is involved, and there can be no expert in all these fields. So the style of the book is simple, almost conversational. The excitement is that we seem to be close to a scientific theory of consciousness. (shrink)

I examine four core aspects of WEAVER ++. The necessity for lemmas is often overstated. A model can incorporate interaction between levels without feedback connections between them. There is some evidence supporting the absence of inhibition in the model. Connectionist modelling avoids the necessity of a nondecompositional semantics apparently required by the hypernym problem.

We present one of the first quantitative studies on auditory verbal experiences and auditory verbal agency voices or characters”) in healthy participants across states of consciousness. Tools of quantitative linguistic analysis were used to measure participants’ implicit knowledge of auditory verbal experiences and auditory verbal agencies, displayed in mentation reports from four different states. Analysis was conducted on a total of 569 mentation reports from rapid eye movement sleep, non-REM sleep, sleep onset, and waking. Physiology was controlled with the nightcap (...) sleep–wake mentation monitoring system. Sleep-onset hallucinations, traditionally at the focus of scientific attention on auditory verbal hallucinations, showed the lowest degree of VE and VA, whereas REM sleep showed the highest degrees. Degrees of different linguistic-pragmatic aspects of VE and VA likewise depend on the physiological states. The quantity and pragmatics of VE and VA are a function of the physiologically distinct state of consciousness in which they are conceived. (shrink)

Graham Priest presents an original exploration of questions concerning the one and the many. He covers a wide range of issues in metaphysics--unity, identity, grounding, mereology, universals, being, intentionality and nothingness--and draws on Western and Asian philosophy as well as paraconsistent logic to offer a radically new treatment of unity.

The article looks at the structure of impossible worlds, and their deployment in the analysis of some intentional notions. In particular, it is argued that one can, in fact, conceive anything, whether or not it is impossible. Thus a semantics of conceivability requires impossible worlds.

Many people hold that there is a distinctive notion of metaphysical necessity. In this paper I explain why I am skeptical about the view. I examine the sorts of considerations that are adduced for it, and argue that they meet equal and opposite considerations.

Reasoning with cases has been a primary focus of those working in AI and law who have attempted to model legal reasoning. In this paper we put forward a formal model of reasoning with cases which captures many of the insights from that previous work. We begin by stating our view of reasoning with cases as a process of constructing, evaluating and applying a theory. Central to our model is a view of the relationship between cases, rules based on cases, (...) and the social values which justify those rules. Having given our view of these relationships, we present our formal model of them, and explain how theories can be constructed, compared and evaluated. We then show how previous work can be described in terms of our model, and discuss extensions to the basic model to accommodate particular features of previous work. We conclude by identifying some directions for future work. (shrink)

This paper addresses the plausibility of practical apatheism: an attitude of apathy or indifference about philosophical questions pertaining to God’s existence grounded in the belief that they lack practical significance. Since apatheism is rarely discussed, we begin by clarifying the position and explaining how it differs from some of the other positions one may take with regard to the existence of God. Afterward, we examine six distinct objections to practical apatheism. Each of these objections posits a different reason for thinking (...) that belief in God is practically significant. Five of these objections prove unsuccessful. The sixth, which appeals to the practical significance of belief in God with respect to our fates in the afterlife, is more promising but nonetheless encounters significant obstacles. Since the success of this objection is controversial, whether we have good grounds to reject practical apatheism should be similarly controversial, and the view should be given further examination. (shrink)

In Animal Ethics in Context, Clare Palmer tries to harmonise two competing approaches to animal ethics. One focuses on the morally relevant capacities that animals possess. The other is the Laissez-Faire Intuition (LFI): the claim that we have duties to assist domesticated animals but should (at least generally) leave wild animals alone. In this paper, I critique the arguments that Palmer offers in favour of the No-Contact LFI - the view that we have (prima facie) duties not to harm wild (...) animals but no duties to assist them. I argue that Palmer's endorsement of the No-Contact LFI is unwarranted. Her arguments actually provide strong reasons to endorse what I call the Gradient View - a position that posits weak presumptive duties to assist wild animals that become stronger as our relations with the animals grow stronger. (shrink)

1.1 In standard modal logics, the worlds are 2-valued in the following sense: there are 2 values that a sentence may take at a world. Technically, however, there is no reason why this has to be the case. The worlds could be many-valued. This paper presents one simple approach to a major family of many-valued modal logics, together with an illustration of why this family is philosophically interesting.

This paper examines one of the historical antecedents of Big Data, the social physics movement. Its origins are in the scientific revolution of the 17th century in Western Europe. But it is not named as such until the middle of the 19th century, and not formally institutionalized until another hundred years later when it is associated with work by George Zipf and John Stewart. Social physics is marked by the belief that large-scale statistical measurement of social variables reveals underlying relational (...) patterns that can be explained by theories and laws found in natural science, and physics in particular. This larger epistemological position is known as monism, the idea that there is only one set of principles that applies to the explanation of both natural and social worlds. Social physics entered geography through the work of the mid-20th-century geographer William Warntz, who developed his own spatial version called “macrogeography.” It involved the computation of large data sets, made ever easier with the contemporaneous development of the computer, joined with the gravitational potential model. Our argument is that Warntz's concerns with numeracy, large data sets, machine-based computing power, relatively simple mathematical formulas drawn from natural science, and an isomorphism between natural and social worlds became grounds on which Big Data later staked its claim to knowledge; it is a past that has not yet passed. (shrink)

The paper describes a new way of thinking about conditionals, in terms of information transfer between worlds. This way of looking at things provides an answer to some of the standard problems concerning conditionals, and undercuts the claim that indicative and subjunctive conditionals are distinct.

There can be little doubt, at least in the Western world, that autonomy is the ruling principle in contemporary bioethics. In spite of its ‘triumph’ however, the dominance of the utilitarian concept of autonomy is being increasingly questioned. In this paper, I explore the nature of autonomy, how it came to displace the Hippocratic tradition in medicine and how different concepts of autonomy have evolved. I argue that the reduction of autonomy to ‘the exercise of personal choice’ in medicine has (...) led to a ‘tyranny of autonomy’ which can be inimical to ethical medical practice rather than conducive to it. I take the case of Kerrie Wooltorton as an illustration of how misplaced adherence to respect for patient autonomy can lead to tragic consequences. An analysis of autonomy based on the work of Rachel Haliburton is described and applied to the role of autonomy in a recent bioethical debate — that arising from Savulescu's proposal that conscientious objection by health-care professionals should not be permit.. (shrink)

How have human cultures engaged with and thought about animals, plants, rocks, clouds, and other elements in their natural surroundings? Do animals and other natural objects have a spirit or soul? What is their relationship to humans? In this new study, Graham Harvey explores current and past animistic beliefs and practices of Native Americans, Maori, Aboriginal Australians, and eco-pagans. He considers the varieties of animism found in these cultures as well as their shared desire to live respectfully within larger (...) natural communities. Drawing on his extensive casework, Harvey also considers the linguistic, performative, ecological, and activist implications of these different animisms. (shrink)

Following recent developments in the literature on axiomatic theories of truth, we investigate an alternative to the widespread habit of formalizing the syntax of the object-language into the object-language itself. We first argue for the proposed revision, elaborating philosophical evidences in favor of it. Secondly, we present a general framework for axiomatic theories of truth with theories of syntax. Different choices of the object theory O will be considered. Moreover, some strengthenings of these theories will be introduced: we will consider (...) extending the theories by the addition of coding axioms or by extending the schemas of O, if present, to the entire vocabulary of our theory of truth. Finally, we touch on the philosophical consequences that the theories described can have on the debate about the metaphysical status of the truth predicate and on the formalization of our informal metatheoretic reasoning. (shrink)

This paper critically examines several game theoretic interpretations of Hobbes' state of nature, including Prisoner's Dilemma and Assurance Game, and argues instead that the best matrix is that of a combination of the two, an Assurance Dilemma. This move is motivated by the fact that Hobbes explicitly notes two distinct personality types, with different preference structures, in the state of nature: dominators and moderates. The former play as if in a Prisoner's Dilemma, the latter play as if in an Assurance (...) Game. But when meeting one another, the Assurance Dilemma represents their differing strategies, and can explain various other features of Hobbes' state of nature, as well as a key informational role played the Sovereign. (shrink)

There is a debate in normative ethics about whether or not our moral obligations depend solely on either our evidence concerning, or our beliefs about, the world. Subjectivists maintain that they do and objectivists maintain that they do not. I shall offer some arguments in support of objectivism and respond to the strongest argument for subjectivism. I shall also briefly consider the significance of my discussion to the debate over whether one’s future voluntary actions are relevant to one’s current moral (...) obligations. (shrink)

This article seeks to demonstrate the centrality of maintenance and repair to an understanding of modern societies and, particularly, cities. Arguing that repair and maintenance activities present a kind of 'missing link' in social theory, which is usually overlooked or forgotten, the article begins by recalling Heidegger's concept of material things as being 'ready to hand'. The main elements of practices of repair and maintenance are then elaborated on so as to help establish the argument that, by focusing on failure (...) and breakdown in technical artefacts and systems, their vital contribution can be brought to the fore. The article then moves on to suggest that prevailing cultural constructions, and imaginations, of the 'infrastructure' that sustains modern societies, actively work to push repair and maintenance activities beyond the attention of social science. To exemplify these arguments, the article explores in detail some of the repair and maintenance activities that sustain, first, the nexus between computer communications and electricity and, second, the system of automobility. The article concludes by excavating a politics of repair and maintenance in modern cities and societies. (shrink)

The first attempt at a systematic approach to axiomatic theories of truth was undertaken by Friedman and Sheard (Ann Pure Appl Log 33:1–21, 1987). There twelve principles consisting of axioms, axiom schemata and rules of inference, each embodying a reasonable property of truth were isolated for study. Working with a base theory of truth conservative over PA, Friedman and Sheard raised the following questions. Which subsets of the Optional Axioms are consistent over the base theory? What are the proof-theoretic strengths (...) of the consistent theories? The first question was answered completely by Friedman and Sheard; all subsets of the Optional Axioms were classified as either consistent or inconsistent giving rise to nine maximal consistent theories of truth.They also determined the proof-theoretic strength of two subsets of the Optional Axioms. The aim of this paper is to continue the work begun by Friedman and Sheard. We will establish the proof-theoretic strength of all the remaining seven theories and relate their arithmetic part to well-known theories ranging from PA to the theory of ${\Sigma^1_1}$ dependent choice. (shrink)

In “On Oppy’s Objections to the Modal Perfection Argument,” Philo 8, 2, 2005, 123–30, Robert Maydole argues that his modal perfection argument—set out in his “The Modal Perfection Argument for a Supreme Being,” Philo 6, 2, 2003, 299–313—“remains arguably sound” in the face of the criticisms that I made of this argument in my “Maydole’s 2QS5 Argument,” Philo 7, 2, 2004, 203–11. I reply that Maydole is wrong: his argument is fatally flawed, and his attempts to avoid the criticisms that (...) I have made of his argument are to no avail. (shrink)

Assisted dying is a divisive and controversial topic and it is therefore desirable that a broad range of interests inform any proposed policy changes. The purpose of this study is to collect and synthesize the views of an important stakeholder group—namely people with disabilities —as expressed by disability rights organisations in Great Britain. Parliamentary consultations were reviewed, together with an examination of the contemporary positions of a wide range of DROs. Our analysis revealed that the vast majority do not have (...) a clear public stance; those that do exhibit a significant diversity of opinion. DROs opposing legislation on assisted dying have argued that it would be premature, misguided, inequitable and culturally undesirable. Some specify conditions that would have to be satisfied before they could support legalisation, such as radical improvements in health and social care services and the elimination of discrimination against PwD. DROs supporting assisted dying maintain that a change in the law would promote autonomy, end intense suffering, can be delivered safely and is supported by the DRO’s membership. The discussion considers the reasons why several DROs adopt a neutral stance and the argument is made that, whatever their overarching stance on the issue, DROs need to be involved in the policy debate so that the crucial perspectives of PwD are heard and addressed. This is an important message for countries around the world that permit, or are considering legalising, assisted dying. (shrink)

Moral dilemmas can arise from uncertainty, including uncertainty of the real values involved. One interesting example of this is that of experimentation on human embryos and foetuses, If these have a moral stauts similar to that of human persons then there will be server constraitns on what may be done to them. If embryous have a moral status similar to that of other small clusters of cells, then constraints will be motivated largely by consideration for the persons into whom the (...) embryos may develop. If the truth lies somewhere between these two extremes, the embryo having neither the full moral weight of persons, nor a completely negligible moral weight, then different kinds of constraints will be appropriate. On the face of it, in order to know what kinds of experiements, if any, we are morally justified in performing on embryos we have to know what the moral weight of the embryo is. But then an impasse threatens, for it seems implausible that we can settle with certainty the exact moral status of the human embryo. It is the purpose of this paper to show that moral uncertainty need not make rational moral justification impossible. I develop a framework which distinguishes between what is morally right/wrong, and what is morally justified/unjustified, and applies standard decision theoretic tools to the case of moral uncertainties. (This was the first published account of what has subsequently become known as Expected Moral Value Theory. An earlier version of the paper, "A decision theoretic argument against human embryo experimentation", was published in M. Fricke (ed.), Essays in honor of Bob Durrant. (University of Otago Press, 1986) 111-27.). (shrink)

In this paper, I will argue that Locke is a substance dualist in the general sense, in that he holds that there are, independent of our classificatory schema, two distinct kinds of substances: wholly material ones and wholly immaterial ones. On Locke’s view, the difference between the two lies in whether they are solid or not, thereby differentiating him from Descartes. My way of establishing Locke as a general substance dualist is to be as minimally committal as possible at the (...) outset, especially with respect to the classic debates on Locke’s positions in this domain, including those concerning substrata, real essences, and the like. Nonetheless, I show that minimal commitments about Locke’s primary/secondary quality distinction are sufficient to derive some substantive conclusions about his positions on these issues, as well as that he is a general substance dualist. (shrink)

The paper discusses the similarity between geometry, arithmetic, and logic, specifically with respect to the question of whether applied theories of each may be revised. It argues that they can - even when the revised logic is a paraconsistent one, or the revised arithmetic is an inconsistent one. Indeed, in the case of logic, it argues that logic is not only revisable, but, during its history, it has been revised. The paper also discusses Quine's well known argument against the possibility (...) of logical deviancy. (shrink)

Only too often critical realist contributions to understanding and explaining social phenomena fall into one of two discrete categories: exercises in philosophy or social theory, or empirical research that strikes as more or less atheoretical. This paper continues a long-term project to build bridges between abstruse issues of philosophy and theory and attempts to grasp the ‘how’ and ‘why’ of actual social events. The topic selected is elite professional rugby union and the principal theme is its emergence as an extreme (...) sport and the risk of serious injury. It is argued that the injurious nature of elite rugby has its causal genesis in the professionalization of the sport and that a critical realist-oriented sociology has an important contribution to make in framing and gasping how and why this is. (shrink)

This brief paper builds on my recently published work on financial capitalism. My objective here is (a) to sketch an account of the primary social features of post-1970s financialised capitalism, (b) to identify select dynamics or mechanisms that have resulted in these features, (c) to outline a programme of research to enhance our explanatory understanding of the ‘fractured society’ via the sociological concepts of structure, culture and agency, and (d) to broach, characterize and assess likely prospects and triggers for the (...) accomplishment of a credible, defensible post-capitalist societal formation. (shrink)

Hsueh M. Qu has recently argued that Hume’s famed ‘Separability Principle’ from the Treatise entangles him in a contradiction. Qu offers a modified principle as a solution but also argues that the mature Hume would not have needed to avail himself of it, given that Hume’s arguments in the first Enquiry do not depend on this principle in any form. To the contrary, I show that arguments in the first Enquiry depend on this principle, but I agree with Qu that (...) Qu’s solution to Hume’s quandary frees him of the contradiction. Next, I compare Qu’s solution to Hume’s original position. By analysing the divergent forms of 'Hume’s Dictum’ that follow from them, I show that Qu’s solution and Hume’s original position have significantly different consequences in a range of domains, including Hume’s modality. Generally, Qu’s solution fits better with Hume’s other commitments—even though Hume often fails to recognize it—thereby increasing its plausibility. (shrink)

Kalam cosmological arguments have recently been the subject of criticisms, at least inter alia, by physicists---Paul Davies, Stephen Hawking---and philosophers of science---Adolf Grunbaum. In a series of recent articles, William Craig has attempted to show that these criticisms are “superficial, iII-conceived, and based on misunderstanding.” I argue that, while some of the discussion of Davies and Hawking is not philosophically sophisticated, the points raised by Davies, Hawking and Grunbaum do suffice to undermine the dialectical efficacy of kalam cosmological arguments.